Cancer immunotherapy : immune suppression and tumor growth /
Cancer immunotherapy : immune suppression and tumor growth /
edited by George Prendergast, Elizabeth M. Jaffee.
- Amsterdam ; Boston : Academic Press/Elsevier, ©2007.
- 1 online resource (xiii, 409 pages, 4 unnumbered pages of plates) : illustrations (some color)
Includes bibliographical references and index.
Part I: Principles of Cancer Immunobiology -- Introduction -- Cancer Immunoediting: From Immune Surveillance to Immune Escape -- Immunosurveillance: Innate and Adaptive Anti-Tumor Immunity -- Cytokine Regulation of Immune Tolerance to Tumors -- Immunological Sculpting: Natural Killer Cell Receptors and Ligands -- Immune Escape: Immunosuppressive Networks -- Part II: Cancer Therapeutics -- Cytotoxic Chemotherapy in Clinical Treatment of Cancer -- Targeted Therapeutics in Cancer Treatment -- Concepts in Pharmacology and Toxicology -- Cancer Immunotherapy: Challenges and Opportunities -- Cancer Vaccines -- Part III: Targets and Tactics to Improve Cancer Immunotherapy By Defeating Immune Suppression -- Immunotherapy and Cancer Therapeutics: Why Partner? -- Immune Stimulatory Features of Classical Chemotherapy -- Dendritic Cells and Co-Inhibitory Molecules -- Regulatory T Cells in Tumor Immunity: Role of Toll-like Receptors -- Tumor-associated Macrophages in Cancer Growth and Progression -- Tumor-associated Myeloid-derived Suppressor Cells -- Programmed Death Ligand-1 and Galectin-1: Pieces in the Puzzle of Tumor Immune Escape -- IDO in Immune Escape: Regulation and Therapeutic Inhibition -- Arginase, Nitric Oxide Synthase, and Novel Inhibitors of L-arginine Metabolism in Immune Modulation -- Summary: Future Questions. Introduction / George C. Prendergast and Elizabeth M. Jaffee -- Cancer immunoediting : from immune surveillance to immune escape / Ryungsa Kim -- Immunosurveillance : innate and adaptive antitumor immunity / Masahisa Jinushi and Glenn Dranoff -- Cytokine regulation of immune tolerance to tumors / Ming O. Li and Richard A. Flavell -- Immunological sculpting : natural killer cell receptors and ligands / David A. Sallman and Julie Y. Djeu -- Immune escape : immunosuppressive networks / Shuang Wei, Alfred Chang, and Weiping Zou -- Cytotoxic chemotherapy in clinical treatment of cancer / Rajesh Thirumaran, George C. Prendergast, and Paul B. Gilman -- Targeted therapeutics in cancer treatment / Colin D. Weekes and Manuel Hidalgo -- Concepts in pharmacology and toxicology / Richard A. Westhouse and Bruce D. Car -- Cancer immunotherapy : challenges and opportunities / Andrew J. Lepisto, John R. McKolanis, and Olivera J. Finn -- Cancer vaccines / Freda K. Stevenson [and others]. Immunotherapy and cancer therapeutics : why partner? / Leisha A. Emens and Elizabeth M. Jaffee -- Immune stimulatory features of classical chemotherapy / Robbert G. van der Most, Anna K. Nowak, and Richard A. Lake -- Dendritic cells and coregulatory signals : immune checkpoint blockade to stimulate immunotherapy / Drew Pardoll -- Regulatory T cells in tumor immunity : role of toll-like receptors / Rong-Fu Wang -- Tumor-associated macrophages in cancer growth and progression / Alberto Mantovani, Paola Allavena, and Antonio Sica -- Tumor-associated myeloid-derived suppressor cells / Stephanie K. Bunt [and others] -- Programmed death ligand-1 and galectin-1 : pieces in the puzzle of tumor-immune escape / Gabriel A. Rabinovich and Thomas F. Gajewski -- Indoleamine 2,3-dioxygenase in immune escape : regulation and therapeutic inhibition / Alexander J. Muller and George C. Prendergast -- Arginase, nitric oxide synthase, and novel inhibitors of L-arginine metabolism in immune modulation / Susanna Mandruzzato, Simone Mocellin, and Vincenzo Bronte.
There has been major growth in understanding immune suppression mechanisms and its relationship to cancer progression and therapy. This book highlights emerging new principles of immune suppression that drive cancer and it offers radically new ideas about how therapy can be improved by attacking these principles. Following work that firmly establishes immune escape as an essential trait of cancer, recent studies have now defined specific mechanisms of tumoral immune suppression. It also demonstrates how attacking tumors with molecular targeted therapeutics or traditional chemotherapeutic drugs can produce potent anti-tumor effects in preclinical models. This book provides basic, translational, and clinical cancer researchers an indispensable overview of immune escape as a critical trait in cancer and how applying specific combinations of immunotherapy and chemotherapy to attack this trait may radically improve the treatment of advanced disease. * Offers a synthesis of concepts that are useful to cancer immunologists and pharmacologists, who tend to work in disparate fields with little cross-communication * Drs Prendergast and Jaffee are internationally recognized leaders in cancer biology and immunology who have created a unique synthesis of fundamental and applied concepts in this important new area of cancer research * Summarizes the latest insights into how immune escape defines an essential trait of cancer * Includes numerous illustrations including: how molecular-targeted therapeutic drugs or traditional chemotherapy can be combined with immunotherapy to improve anti-tumor efficacy; and how reversing immune suppression by the tumor can cause tumor regression.
English.
9780123725516 0123725518 9780080521855 (electronic bk.) 0080521851 (electronic bk.) 1281020451 9781281020451 9786611020453 6611020454
133760:133886 Elsevier Science & Technology http://www.sciencedirect.com
Cancer--Immunotherapy.
Antineoplastic agents--Therapeutic use.
Tumors--Immunological aspects.
Neoplasms--therapy
Immunotherapy--methods
Cancer--Immunothérapie.
Anticancéreux--Emploi en thérapeutique.
Tumeurs--Immunologie.
MEDICAL--Oncology.
HEALTH & FITNESS--Diseases--Cancer.
Antineoplastic agents--Therapeutic use.
Cancer--Immunotherapy.
Tumors--Immunological aspects.
Electronic books.
RC271.I45 / C363 2007eb
616.99/4061
QZ 266 / C2146 2007
Includes bibliographical references and index.
Part I: Principles of Cancer Immunobiology -- Introduction -- Cancer Immunoediting: From Immune Surveillance to Immune Escape -- Immunosurveillance: Innate and Adaptive Anti-Tumor Immunity -- Cytokine Regulation of Immune Tolerance to Tumors -- Immunological Sculpting: Natural Killer Cell Receptors and Ligands -- Immune Escape: Immunosuppressive Networks -- Part II: Cancer Therapeutics -- Cytotoxic Chemotherapy in Clinical Treatment of Cancer -- Targeted Therapeutics in Cancer Treatment -- Concepts in Pharmacology and Toxicology -- Cancer Immunotherapy: Challenges and Opportunities -- Cancer Vaccines -- Part III: Targets and Tactics to Improve Cancer Immunotherapy By Defeating Immune Suppression -- Immunotherapy and Cancer Therapeutics: Why Partner? -- Immune Stimulatory Features of Classical Chemotherapy -- Dendritic Cells and Co-Inhibitory Molecules -- Regulatory T Cells in Tumor Immunity: Role of Toll-like Receptors -- Tumor-associated Macrophages in Cancer Growth and Progression -- Tumor-associated Myeloid-derived Suppressor Cells -- Programmed Death Ligand-1 and Galectin-1: Pieces in the Puzzle of Tumor Immune Escape -- IDO in Immune Escape: Regulation and Therapeutic Inhibition -- Arginase, Nitric Oxide Synthase, and Novel Inhibitors of L-arginine Metabolism in Immune Modulation -- Summary: Future Questions. Introduction / George C. Prendergast and Elizabeth M. Jaffee -- Cancer immunoediting : from immune surveillance to immune escape / Ryungsa Kim -- Immunosurveillance : innate and adaptive antitumor immunity / Masahisa Jinushi and Glenn Dranoff -- Cytokine regulation of immune tolerance to tumors / Ming O. Li and Richard A. Flavell -- Immunological sculpting : natural killer cell receptors and ligands / David A. Sallman and Julie Y. Djeu -- Immune escape : immunosuppressive networks / Shuang Wei, Alfred Chang, and Weiping Zou -- Cytotoxic chemotherapy in clinical treatment of cancer / Rajesh Thirumaran, George C. Prendergast, and Paul B. Gilman -- Targeted therapeutics in cancer treatment / Colin D. Weekes and Manuel Hidalgo -- Concepts in pharmacology and toxicology / Richard A. Westhouse and Bruce D. Car -- Cancer immunotherapy : challenges and opportunities / Andrew J. Lepisto, John R. McKolanis, and Olivera J. Finn -- Cancer vaccines / Freda K. Stevenson [and others]. Immunotherapy and cancer therapeutics : why partner? / Leisha A. Emens and Elizabeth M. Jaffee -- Immune stimulatory features of classical chemotherapy / Robbert G. van der Most, Anna K. Nowak, and Richard A. Lake -- Dendritic cells and coregulatory signals : immune checkpoint blockade to stimulate immunotherapy / Drew Pardoll -- Regulatory T cells in tumor immunity : role of toll-like receptors / Rong-Fu Wang -- Tumor-associated macrophages in cancer growth and progression / Alberto Mantovani, Paola Allavena, and Antonio Sica -- Tumor-associated myeloid-derived suppressor cells / Stephanie K. Bunt [and others] -- Programmed death ligand-1 and galectin-1 : pieces in the puzzle of tumor-immune escape / Gabriel A. Rabinovich and Thomas F. Gajewski -- Indoleamine 2,3-dioxygenase in immune escape : regulation and therapeutic inhibition / Alexander J. Muller and George C. Prendergast -- Arginase, nitric oxide synthase, and novel inhibitors of L-arginine metabolism in immune modulation / Susanna Mandruzzato, Simone Mocellin, and Vincenzo Bronte.
There has been major growth in understanding immune suppression mechanisms and its relationship to cancer progression and therapy. This book highlights emerging new principles of immune suppression that drive cancer and it offers radically new ideas about how therapy can be improved by attacking these principles. Following work that firmly establishes immune escape as an essential trait of cancer, recent studies have now defined specific mechanisms of tumoral immune suppression. It also demonstrates how attacking tumors with molecular targeted therapeutics or traditional chemotherapeutic drugs can produce potent anti-tumor effects in preclinical models. This book provides basic, translational, and clinical cancer researchers an indispensable overview of immune escape as a critical trait in cancer and how applying specific combinations of immunotherapy and chemotherapy to attack this trait may radically improve the treatment of advanced disease. * Offers a synthesis of concepts that are useful to cancer immunologists and pharmacologists, who tend to work in disparate fields with little cross-communication * Drs Prendergast and Jaffee are internationally recognized leaders in cancer biology and immunology who have created a unique synthesis of fundamental and applied concepts in this important new area of cancer research * Summarizes the latest insights into how immune escape defines an essential trait of cancer * Includes numerous illustrations including: how molecular-targeted therapeutic drugs or traditional chemotherapy can be combined with immunotherapy to improve anti-tumor efficacy; and how reversing immune suppression by the tumor can cause tumor regression.
English.
9780123725516 0123725518 9780080521855 (electronic bk.) 0080521851 (electronic bk.) 1281020451 9781281020451 9786611020453 6611020454
133760:133886 Elsevier Science & Technology http://www.sciencedirect.com
Cancer--Immunotherapy.
Antineoplastic agents--Therapeutic use.
Tumors--Immunological aspects.
Neoplasms--therapy
Immunotherapy--methods
Cancer--Immunothérapie.
Anticancéreux--Emploi en thérapeutique.
Tumeurs--Immunologie.
MEDICAL--Oncology.
HEALTH & FITNESS--Diseases--Cancer.
Antineoplastic agents--Therapeutic use.
Cancer--Immunotherapy.
Tumors--Immunological aspects.
Electronic books.
RC271.I45 / C363 2007eb
616.99/4061
QZ 266 / C2146 2007