Lipid Rafts : Properties and Role in Signaling.
Lipid Rafts : Properties and Role in Signaling.
- New York : Nova Science Publishers, Incorporated, 2018.
- 1 online resource (168 pages)
- Biochemistry research trends series .
- Biochemistry research trends series. .
Intro; Contents; Preface; Chapter 1; Jak1 as the Architect for Assembling and Activating Multi-Chain Cytokine Receptor Complexes in Lipid Rafts; Abstract; Abbreviations; About Lipid Rafts; Conceptualizing Multiple Liquid Phases; The Lipid Bilayer Plasma Membrane as a 2-Dimensional Liquid; The Biophysics of Lipid Raft Domains vs. Non-Raft Domains; The Chemistry of Lipids and Lipid Rafts; Biophysical Studies: Lipid Rafts, Detergent Resistant Membranes and Synthetic Membranes; Synthetic and Reconstituted Lipid Bilayer Membranes; Endogenous Lipid Raft Detergents?; From the Research to the Model. The Biology of Lipid RaftsFRET as a Nanometer-Limited Visualization Technology; The Biological Problem Being Addressed; 1. IFN- R1 and IFN- R2 Interact Constitutively in Cells; 2. Jak1 Needed for IFN- R1 to Interact with IFN- R2, or for Other Cytokine Receptor Pairs to Interact; 3. Jak1 Needed for High Affinity between Cytokine Receptor Chains; Influence of Lipid Raft Association for Cytokine Receptor Chain Interaction; 4. Lipid Raft Association with IFN- R1 Needed for Interaction with IFN- R2; 5. Jak1 Association with IFN- R1 Necessary for High-Affinity Lipid Raft Association. 6. Only Low-Level Jak1 Associated with Membrane Correlates with Strongest IFN- R1 and IFN- R2 InteractionConclusion; References; Chapter 2; The Implication of Rafts in Atherosclerosis, Cancer or Neurodegenerative Diseases; Abstract; Introduction; Properties of Lipid Rafts; Cholesterol -- Oxysterols: Potent Modulators of Lipid Raft Formation; Role of Lipid Rafts in Signaling; Inflammation Process -- Atherogenesis; Lipid Rafts and Neurodegeneration (Marin et al., 2013); Lipid Rafts and Cancer (Zalba and Ten Hagen, 2017, Mollinedo and Gajate, 2015); Lipid Rafts and Aging; Conclusion; References. 2.1. Lipids and Other Chemicals Were Obtained as Follows2.2. Preparation of Triton-Insoluble Fraction; 2.3. Protein Preparation; 3. Results; 3.1. Triton-Insolubility of Phospholipid and the Effect of CHL; Discussion; Conclusion; Acknowledgment; Conflict of Interest; Ethical Statement; References; Index; Blank Page.
9781536136258 (electronic bk.) 1536136255 (electronic bk.)
Membrane lipids.
Membrane Lipids
Lipides membranaires.
SCIENCE--Life Sciences--Biochemistry.
Membrane lipids.
Electronic books.
QP752.M45
572/.577
Intro; Contents; Preface; Chapter 1; Jak1 as the Architect for Assembling and Activating Multi-Chain Cytokine Receptor Complexes in Lipid Rafts; Abstract; Abbreviations; About Lipid Rafts; Conceptualizing Multiple Liquid Phases; The Lipid Bilayer Plasma Membrane as a 2-Dimensional Liquid; The Biophysics of Lipid Raft Domains vs. Non-Raft Domains; The Chemistry of Lipids and Lipid Rafts; Biophysical Studies: Lipid Rafts, Detergent Resistant Membranes and Synthetic Membranes; Synthetic and Reconstituted Lipid Bilayer Membranes; Endogenous Lipid Raft Detergents?; From the Research to the Model. The Biology of Lipid RaftsFRET as a Nanometer-Limited Visualization Technology; The Biological Problem Being Addressed; 1. IFN- R1 and IFN- R2 Interact Constitutively in Cells; 2. Jak1 Needed for IFN- R1 to Interact with IFN- R2, or for Other Cytokine Receptor Pairs to Interact; 3. Jak1 Needed for High Affinity between Cytokine Receptor Chains; Influence of Lipid Raft Association for Cytokine Receptor Chain Interaction; 4. Lipid Raft Association with IFN- R1 Needed for Interaction with IFN- R2; 5. Jak1 Association with IFN- R1 Necessary for High-Affinity Lipid Raft Association. 6. Only Low-Level Jak1 Associated with Membrane Correlates with Strongest IFN- R1 and IFN- R2 InteractionConclusion; References; Chapter 2; The Implication of Rafts in Atherosclerosis, Cancer or Neurodegenerative Diseases; Abstract; Introduction; Properties of Lipid Rafts; Cholesterol -- Oxysterols: Potent Modulators of Lipid Raft Formation; Role of Lipid Rafts in Signaling; Inflammation Process -- Atherogenesis; Lipid Rafts and Neurodegeneration (Marin et al., 2013); Lipid Rafts and Cancer (Zalba and Ten Hagen, 2017, Mollinedo and Gajate, 2015); Lipid Rafts and Aging; Conclusion; References. 2.1. Lipids and Other Chemicals Were Obtained as Follows2.2. Preparation of Triton-Insoluble Fraction; 2.3. Protein Preparation; 3. Results; 3.1. Triton-Insolubility of Phospholipid and the Effect of CHL; Discussion; Conclusion; Acknowledgment; Conflict of Interest; Ethical Statement; References; Index; Blank Page.
9781536136258 (electronic bk.) 1536136255 (electronic bk.)
Membrane lipids.
Membrane Lipids
Lipides membranaires.
SCIENCE--Life Sciences--Biochemistry.
Membrane lipids.
Electronic books.
QP752.M45
572/.577