Contraceptive risk : the FDA, Depo-Provera, and the politics of experimental medicine /
Green, William, 1950-
Contraceptive risk : the FDA, Depo-Provera, and the politics of experimental medicine / William Green. - 1 online resource
Includes bibliographical references and index.
Introduction : the odyssey of Depo-Provera -- The Grady Hospital study : the corruption of contraceptive research -- The twenty-five-year FDA approval controversy : cancer and the politics of acceptable risk -- Contraceptive chaos : unapproved use and Upjohn v. MacMurdo -- Marketing approval and litigation : osteoporosis and the realities of medical risk -- Chemical castration : the John Hopkins Clinic and People v. Gauntlett -- Conclusions : contraceptive drug risk failure, human dignity, and a duty to act.
Depo-Provera is known as an injectable hormonal birth control method, but few are familiar with its dark and complicated history. Depo-Provera was tested on women since the mid-1960s without their informed consent until it was FDA-approved in 1992, but never FDA-approved as chemical castration for male sex offenders. Contraceptive risk is the author's landmark study of Depo-Provera. Based on a fascinating combination of archival materials and interviews, the book is framed as three interconnected stories told by Judith Weisz, who chaired the FDA's Public Board of Inquiry on Depo-Provera, a scientific court; by Anne MacMurdo who brought a products liability suit against Upjohn, the drug's manufacturer, for the deleterious side effects she suffered from the drug's use; and by Roger Gauntlett, an Upjohn heir who, when he was convicted of sexual assault, refused to take a dose of his family's own medicine as a probation condition. Together these three stories of Depo-Provera's convoluted fifty year odyssey call for a paradigm shift in pharmaceutical drug development. Contraceptive risk is a thoroughly researched and engrossing approach to the scientific, political and institutional forces involved in health law and policy, as well as the multifaceted politics of measuring risk.--description from back cover.
9781479825929 (electronic bk.) 1479825921 (electronic bk.)
Contraception.
Women--Health risk assessment.
Contraceptives--Safety measures.
Contraception--history
Medroxyprogesterone Acetate--history
Contraception
Contraception.
Femmes--Risques pour la santé--Évaluation.
Contraceptifs--Sécurité--Mesures.
MEDICAL--Gynecology & Obstetrics.
Contraception.
Women--Health risk assessment.
Electronic books.
RG136 / .G67 2017eb
618.1/8
WP 630
Contraceptive risk : the FDA, Depo-Provera, and the politics of experimental medicine / William Green. - 1 online resource
Includes bibliographical references and index.
Introduction : the odyssey of Depo-Provera -- The Grady Hospital study : the corruption of contraceptive research -- The twenty-five-year FDA approval controversy : cancer and the politics of acceptable risk -- Contraceptive chaos : unapproved use and Upjohn v. MacMurdo -- Marketing approval and litigation : osteoporosis and the realities of medical risk -- Chemical castration : the John Hopkins Clinic and People v. Gauntlett -- Conclusions : contraceptive drug risk failure, human dignity, and a duty to act.
Depo-Provera is known as an injectable hormonal birth control method, but few are familiar with its dark and complicated history. Depo-Provera was tested on women since the mid-1960s without their informed consent until it was FDA-approved in 1992, but never FDA-approved as chemical castration for male sex offenders. Contraceptive risk is the author's landmark study of Depo-Provera. Based on a fascinating combination of archival materials and interviews, the book is framed as three interconnected stories told by Judith Weisz, who chaired the FDA's Public Board of Inquiry on Depo-Provera, a scientific court; by Anne MacMurdo who brought a products liability suit against Upjohn, the drug's manufacturer, for the deleterious side effects she suffered from the drug's use; and by Roger Gauntlett, an Upjohn heir who, when he was convicted of sexual assault, refused to take a dose of his family's own medicine as a probation condition. Together these three stories of Depo-Provera's convoluted fifty year odyssey call for a paradigm shift in pharmaceutical drug development. Contraceptive risk is a thoroughly researched and engrossing approach to the scientific, political and institutional forces involved in health law and policy, as well as the multifaceted politics of measuring risk.--description from back cover.
9781479825929 (electronic bk.) 1479825921 (electronic bk.)
Contraception.
Women--Health risk assessment.
Contraceptives--Safety measures.
Contraception--history
Medroxyprogesterone Acetate--history
Contraception
Contraception.
Femmes--Risques pour la santé--Évaluation.
Contraceptifs--Sécurité--Mesures.
MEDICAL--Gynecology & Obstetrics.
Contraception.
Women--Health risk assessment.
Electronic books.
RG136 / .G67 2017eb
618.1/8
WP 630