Normal view MARC view ISBD view

Prions and prion diseases : new developments / Jean-Michel Verdier, editor. - 1 online resource. - Protein biochemistry, synthesis, structure, and cellular functions Protein science and engineering . - Protein biochemistry, synthesis, structure, and cellular functions series. Protein science and engineering. .

Includes bibliographical references and index.

PRIONS AND PRION DISEASES -- PRIONS AND PRION DISEASES -- CONTENTS -- PREFACE -- NEUROPATHOLOGY OF HUMAN PRION DISEASES -- ABSTRACT -- INTRODUCTION -- THE ROLE OF NEUROPATHOLOGY -- PERFORMING THE AUTOPSY -- NEUROPATHOLOGICAL EXAMINATION -- A.) Macroscopy -- B.) Work-Up for Histological Evaluation -- C.) Microscopic Assessment -- I.) Spongiform Change of the Neuropil -- a) In Sporadic Forms -- b.) In Genetic Forms -- c.) In Acquired Forms -- II) Neuronal Death -- a.) In Sporadic Forms -- b.) In Genetic Forms -- c.) In Acquired Forms SYNAPTIC PATHOLOGY III.) Astroglial Proliferation -- IV.) Microglial Activation -- V.) PrP Amyloid Plaques -- a.) In Sporadic Forms -- b.) In Genetic Forms -- c.) In Acquired Forms -- VI.) Cerebellar Pathology -- a.) In Sporadic Forms -- b.) In Genetic Forms -- c.) In Acquired Forms -- RELATIVE RESISTANCE OF HIPPOCAMPUS IN CJD -- VII.) Detection of PrP -- VIIa.) By Immunohistochemistry -- a.) In Sporadic Forms -- b.) In Genetic Forms -- c.) In Acquired Forms -- VIIb.) By histoblot and Paraffin-Embedded Tissue Blot VIId.) By Western blota.) In Sporadic Forms -- b.) In Genetic Forms -- c.) In Acquired Forms -- VIII.) Co-deposition of other Abnormal Protein Aggregates in CJD -- a) In Sporadic Forms -- b) In Genetic Forms -- c) In Acquired Forms -- IX.) Differential Diagnoses from Autopsy Series -- X.) Neuronal Systems and Their Clinico-Pathological Correlates -- CONCLUSION -- ACKNOWLEDGMENTS -- REFERENCES -- THE NATURE OF THE INFECTIOUS AGENTS: PRP MODELS OF RESISTANT SPECIES TO PRION DISEASES (DOG, RABBIT AND HORSES) -- Abstract -- 1. Introduction 2. MaterialsandMethods3. ResultsandDiscussion -- 4. Conclusion -- Acknowledgments -- References -- INDUCING TRANSMISSIBLE PRION DISEASES WITH RECOMBINANT FIBRILS: A NEW CONCEPT ON GENESIS AND EVOLUTION OF INFECTIOUS PRIONS -- ABSTRACT -- GENERATING TRANSMISSIBLE PRION DISEASES DE NOVO -- THE MECHANISM OF TRIGGERING PRION DISEASE BY RPRP AMYLOID FIBRILS -- EXPERIMENTAL EVIDENCE SUPPORT THE SECOND MODEL -- THE HYPOTHESIS OF DEFORMED TEMPLATING -- CONFORMATIONAL SWITCHING WITHIN INDIVIDUAL AMYLOID FIBRILS AND STRAIN ADAPTATION PHENOMENON CROSS-TALK BETWEEN AMYLOIDOGENIC PROTEINS REFERENCES -- SYNTHETIC PRIONS -- ABSTRACT -- 1. INTRODUCTION -- 2. STRATEGIES FOR DE NOVO MAMMALIAN PRIONS GENERATION -- 2.1. Cell-Free Assay Using Mammalian Prions -- 2.2. De Novo Generation of Prions by Mouse Transgenesis -- 2.3. In Vitro De Novo Prions by PMCA -- 2.4. De Novo Prions by Amyloid Seeding Assay -- 2.5. De Novo Prions by Annealing Technique -- 2.6. Concluding Remarks and New Emerging Techniques for Prion Detection and Generation -- 3. STRUCTURAL BIOLOGY OF NATURAL AND SYNTHETIC PRIONS


English.

ISBN: 9781619427686 (ebook) 1619427680 (hardback)

LCCN: 2020679745

Subjects--Topical Terms:
Prions.
Prion diseases.
Prions (Virologie)
Maladies à prions.
SCIENCE--Life Sciences--Biology.
SCIENCE--Life Sciences--Microbiology.
Prion diseases.
Prions.

Index Terms--Genre/Form:
Electronic books.
Electronic books.

LC Class. No.: QR502

Dewey Class. No.: 573.8/639929