The spectrum of mineral and bone disorders in chronic kidney disease /
The spectrum of mineral and bone disorders in chronic kidney disease /
edited by Klaus Olgaard, Isidro B. Salusky, Justin Silver.
- Second edition.
- 1 online resource (xxvi, 590 pages) : illustrations (some color)
- Oxford clinical nephrology series .
- Oxford clinical nephrology series. .
Revised edition of: The spectrum of renal osteodystrophy / edited by Tilman Drüeke, Isidro B. Salusky. c2001.
Includes bibliographical references and index.
Contributors; List of Abbreviations; Introduction; 1 Definition and classification of renal osteodystrophy and chronic kidney disease-mineral bone disorder (CKD-MBD); Renal osteodystrophy; Chronic kidney disease-mineral bone disorder; Conclusion; References; 2 New aspects of normal bone biology; Introduction; Osteoclasts; Osteoblasts; Osteocytes; Systemic hormones; Summary; References; 3 Osteocytes and mineral metabolism; Introduction; The osteoblast/osteocyte lineage; Osteocyte role in mineralization; Roles of osteocytes in the control of Pi homeostasis Osteocytes' role in phosphate dysregulation associated with CKDThe influence of CKD on osteocyte function; Summary; References; 4 Calcium-sensing receptors (CaSR) in kidney, bone, and vessels; Introduction; Expression, structure, and signaling of the extracellular CaSR; CaSR in the kidney; CaSR and bone; The CaSR and blood vessels; Summary; References; 5 Regulation of parathyroid hormone biosynthesis and gene expression; Introduction; Regulation of PTH expression by 1,25(OH)[sub(2)] vitamin D; Post-transcriptional regulation of PTH gene expression by calcium, phosphate, and CKD Fibroblast growth factor-23 and PTH gene expressionConclusions; References; 6 Abnormal parathyroid gland function in CKD; Introduction; Regulation of PTH gene transcription in CKD; Regulation of PTH release in CKD; Phosphate and abnormal PTH synthesis and secretion in CKD; Vitamin D and abnormal PTH synthesis and secretion in CKD; Abnormal PTH synthesis and secretion due to other factors; Post-transcriptional modulation of PTH synthesis in CKD; Changes in the intracellular and peripheral metabolism of PTH in CKD; Hyperplasia of parathyroid glands in CKD Parathyroid function and VDR polymorphismsControl of increased parathyroid mass; Parathyroid tissue apoptosis and necrosis; Summary; References; 7 PTHrP physiology and pathophysiology, and the PTH/PTHrP receptor; Introduction; Characteristics of the PTHrP gene; Regulation of PTHrP production; Processing and degradation of PTHrP; Physiological actions of PTHrP; Mechanisms of action of PTHrP; PTH/PTHrP receptor expression in renal osteodystrophy; Summary; References; 8 Vitamin D metabolism and action in CKD; Introduction; 25-Hydroxyvitamin D deficiency in CKD; Calcitriol production in CKD The vitamin D receptorEffects of declining 1,25-dihydroxyvitamin D on mineral metabolism; Non-traditional actions of vitamin D; Cardiac effects of calcitriol; Vitamin D and the immune system; Additional effects of vitamin D; Vitamin D and survival in CKD; Summary; References; 9 Growth factors and cytokines in renal bone disease; Introduction; The cells of bone; Bone remodeling; Effects of uremia on skeletal biology; References; 10 Bone histomorphometry in renal osteodystrophy; Historical perspective of renal osteodystrophy; Pathology of different forms of renal osteodystrophy
This new edition is fully updated to reflect the most current thinking and understanding in the field, as presented by a team of international clinical experts.
English.
9780191029325 (electronic bk.) 0191029327 (electronic bk.) 0191753351 9780191753350
Renal osteodystrophy.
Chronic Kidney Disease-Mineral and Bone Disorder
Renal Insufficiency, Chronic--complications
Ostéodystrophie rénale.
HEALTH & FITNESS--Diseases--General.
MEDICAL--Clinical Medicine.
MEDICAL--Diseases.
MEDICAL--Evidence-Based Medicine.
MEDICAL--Internal Medicine.
Renal osteodystrophy.
Chronische Niereninsuffizienz
Knochenstoffwechsel
Mineralstoffwechselstörung
Chronische Niereninsuffizienz.
Knochenstoffwechsel.
Mineralstoffwechselstörung.
Electronic books.
RC931.R4 / S646 2010eb
616.61
2010 J-733 WD 200.5.C2
Revised edition of: The spectrum of renal osteodystrophy / edited by Tilman Drüeke, Isidro B. Salusky. c2001.
Includes bibliographical references and index.
Contributors; List of Abbreviations; Introduction; 1 Definition and classification of renal osteodystrophy and chronic kidney disease-mineral bone disorder (CKD-MBD); Renal osteodystrophy; Chronic kidney disease-mineral bone disorder; Conclusion; References; 2 New aspects of normal bone biology; Introduction; Osteoclasts; Osteoblasts; Osteocytes; Systemic hormones; Summary; References; 3 Osteocytes and mineral metabolism; Introduction; The osteoblast/osteocyte lineage; Osteocyte role in mineralization; Roles of osteocytes in the control of Pi homeostasis Osteocytes' role in phosphate dysregulation associated with CKDThe influence of CKD on osteocyte function; Summary; References; 4 Calcium-sensing receptors (CaSR) in kidney, bone, and vessels; Introduction; Expression, structure, and signaling of the extracellular CaSR; CaSR in the kidney; CaSR and bone; The CaSR and blood vessels; Summary; References; 5 Regulation of parathyroid hormone biosynthesis and gene expression; Introduction; Regulation of PTH expression by 1,25(OH)[sub(2)] vitamin D; Post-transcriptional regulation of PTH gene expression by calcium, phosphate, and CKD Fibroblast growth factor-23 and PTH gene expressionConclusions; References; 6 Abnormal parathyroid gland function in CKD; Introduction; Regulation of PTH gene transcription in CKD; Regulation of PTH release in CKD; Phosphate and abnormal PTH synthesis and secretion in CKD; Vitamin D and abnormal PTH synthesis and secretion in CKD; Abnormal PTH synthesis and secretion due to other factors; Post-transcriptional modulation of PTH synthesis in CKD; Changes in the intracellular and peripheral metabolism of PTH in CKD; Hyperplasia of parathyroid glands in CKD Parathyroid function and VDR polymorphismsControl of increased parathyroid mass; Parathyroid tissue apoptosis and necrosis; Summary; References; 7 PTHrP physiology and pathophysiology, and the PTH/PTHrP receptor; Introduction; Characteristics of the PTHrP gene; Regulation of PTHrP production; Processing and degradation of PTHrP; Physiological actions of PTHrP; Mechanisms of action of PTHrP; PTH/PTHrP receptor expression in renal osteodystrophy; Summary; References; 8 Vitamin D metabolism and action in CKD; Introduction; 25-Hydroxyvitamin D deficiency in CKD; Calcitriol production in CKD The vitamin D receptorEffects of declining 1,25-dihydroxyvitamin D on mineral metabolism; Non-traditional actions of vitamin D; Cardiac effects of calcitriol; Vitamin D and the immune system; Additional effects of vitamin D; Vitamin D and survival in CKD; Summary; References; 9 Growth factors and cytokines in renal bone disease; Introduction; The cells of bone; Bone remodeling; Effects of uremia on skeletal biology; References; 10 Bone histomorphometry in renal osteodystrophy; Historical perspective of renal osteodystrophy; Pathology of different forms of renal osteodystrophy
This new edition is fully updated to reflect the most current thinking and understanding in the field, as presented by a team of international clinical experts.
English.
9780191029325 (electronic bk.) 0191029327 (electronic bk.) 0191753351 9780191753350
Renal osteodystrophy.
Chronic Kidney Disease-Mineral and Bone Disorder
Renal Insufficiency, Chronic--complications
Ostéodystrophie rénale.
HEALTH & FITNESS--Diseases--General.
MEDICAL--Clinical Medicine.
MEDICAL--Diseases.
MEDICAL--Evidence-Based Medicine.
MEDICAL--Internal Medicine.
Renal osteodystrophy.
Chronische Niereninsuffizienz
Knochenstoffwechsel
Mineralstoffwechselstörung
Chronische Niereninsuffizienz.
Knochenstoffwechsel.
Mineralstoffwechselstörung.
Electronic books.
RC931.R4 / S646 2010eb
616.61
2010 J-733 WD 200.5.C2