Animal models in cancer research and human disease : applications, outcomes and controversies /
Animal models in cancer research and human disease : applications, outcomes and controversies /
Sean A. Murray, editor.
- 1 online resource
- Microbiology research andvances Animal science, issues and professions .
- Microbiology research advances series. Animal science, issues, and professions series. .
Includes bibliographical references and index.
ANIMAL MODELS IN CANCER RESEARCH AND HUMAN DISEASE ; ANIMAL MODELS IN CANCER RESEARCH AND HUMAN DISEASE ; Contents ; Preface ; Murine Models of Sporadic and Inflammation-Related Colon Carcinogenesis with Particular Focus on the AOM/DSS Chemically Induced Colorectal Cancer Model ; Abstract ; Introduction ; A Variety of CRC Models: Benefits and Limits ; Chemically Induced Colon Carcinogenesis in Rodents ; The AOM/DSS Model in the Study of Colorectal Carcinogenesis ; Histogenesis of Colon Cancer in AOM/DSS Model -- from the Emergence of Precancerous Lesions to Late Carcinomas. Molecular Events Associated with Colon Carcinogenesis in the AOM/DSS Model and Relevance for Human CRC Wnt/APC/Ý-Catenin Pathway ; K-Ras ; c-Myc ; TGF-Ý ; Cox-2 ; iNOS ; p53 Pathway ; Epigenetic Modifications ; Pathogenesis and Molecular Biology of Colitis-Induced Carcinogenesis in the AOM/DSS Model; Proinflammatory Factors ; Regulatory Factors ; Chemokines ; Toll Like Receptors ; TIR8 ; Heparanase ; Oxidative Stress and DNA Damage; The AOM/DSS Model in Preclinical Studies ; Natural Plant Compounds ; Modulation of Physiological Molecules ; Synthetic Drugs ; Conclusion ; Acknowledgment. 3.3. Mechanical Injury Induced Neointimal Hyperplasia 4. Animal Models of Structural Heart Disease ; 4.1. Ischemic Mitral Regurgitation ; Conclusion ; Acknowledgment ; References ; Canine Breast Cancer and Lymphoma as Modelsin Cancer Research ; Abstract ; 1. Introduction ; 1.1. Dogs as Appropriate Animal Models of Human Cancers ; 2. Canine Mammary Tumor Model ; 2.1. Expression Defects of Cell Cycle Regulators in the CMT Model ; Deregulation of p16/INK4A/ARF/INK4B Locus in CMTs ; 2.2. Genome-Wide Comparative Analysis of the Role of Critical Genes Involved in Human and Canine Mammary Tumors. 2.3. Expression of miRNAs in Human Breast Cancer and the CMT Model 3. Canine Lymphoma Model ; Conclusion ; References ; Development of Cell Therapeutic Strategies for Alzheimer's Disease Using Animal Models ; Abstract ; Introduction ; Amyloid Cascade Hypothesis ; Transgenic Mice Models of AD ; Therapeutic Strategies Using Transgenic Mice Models of AD ; Microglia in the AD Brain ; Cell Therapeutic Strategies for AD ; Conclusion ; Acknowledgments ; References ; Animal Models for AntineoplasticChemotherapy-Induced Alopecia; Abstract ; Introduction ; The Biology of the Hair Follicles (HFs)
9781624175886 (ebook) 1624175880 (hardback) (hbk.)
99954336392
2020687970
GBB349989 bnb
016416249 Uk
Carcinogenesis--Animal models.
Diseases--Animal models.
Animal models in research--Moral and ethical aspects.
Research.
Disease Models, Animal
Research
Ethics
Carcinogenesis
Cancérogenèse--Modèles animaux.
Maladies--Modèles animaux.
Modèles animaux dans la recherche--Aspect moral.
Recherche.
research (function)
MEDICAL--Research.
Carcinogenesis--Animal models.
Diseases--Animal models.
Electronic books.
7
Electronic books.
RC268.5
616.0273
QY 58
Includes bibliographical references and index.
ANIMAL MODELS IN CANCER RESEARCH AND HUMAN DISEASE ; ANIMAL MODELS IN CANCER RESEARCH AND HUMAN DISEASE ; Contents ; Preface ; Murine Models of Sporadic and Inflammation-Related Colon Carcinogenesis with Particular Focus on the AOM/DSS Chemically Induced Colorectal Cancer Model ; Abstract ; Introduction ; A Variety of CRC Models: Benefits and Limits ; Chemically Induced Colon Carcinogenesis in Rodents ; The AOM/DSS Model in the Study of Colorectal Carcinogenesis ; Histogenesis of Colon Cancer in AOM/DSS Model -- from the Emergence of Precancerous Lesions to Late Carcinomas. Molecular Events Associated with Colon Carcinogenesis in the AOM/DSS Model and Relevance for Human CRC Wnt/APC/Ý-Catenin Pathway ; K-Ras ; c-Myc ; TGF-Ý ; Cox-2 ; iNOS ; p53 Pathway ; Epigenetic Modifications ; Pathogenesis and Molecular Biology of Colitis-Induced Carcinogenesis in the AOM/DSS Model; Proinflammatory Factors ; Regulatory Factors ; Chemokines ; Toll Like Receptors ; TIR8 ; Heparanase ; Oxidative Stress and DNA Damage; The AOM/DSS Model in Preclinical Studies ; Natural Plant Compounds ; Modulation of Physiological Molecules ; Synthetic Drugs ; Conclusion ; Acknowledgment. 3.3. Mechanical Injury Induced Neointimal Hyperplasia 4. Animal Models of Structural Heart Disease ; 4.1. Ischemic Mitral Regurgitation ; Conclusion ; Acknowledgment ; References ; Canine Breast Cancer and Lymphoma as Modelsin Cancer Research ; Abstract ; 1. Introduction ; 1.1. Dogs as Appropriate Animal Models of Human Cancers ; 2. Canine Mammary Tumor Model ; 2.1. Expression Defects of Cell Cycle Regulators in the CMT Model ; Deregulation of p16/INK4A/ARF/INK4B Locus in CMTs ; 2.2. Genome-Wide Comparative Analysis of the Role of Critical Genes Involved in Human and Canine Mammary Tumors. 2.3. Expression of miRNAs in Human Breast Cancer and the CMT Model 3. Canine Lymphoma Model ; Conclusion ; References ; Development of Cell Therapeutic Strategies for Alzheimer's Disease Using Animal Models ; Abstract ; Introduction ; Amyloid Cascade Hypothesis ; Transgenic Mice Models of AD ; Therapeutic Strategies Using Transgenic Mice Models of AD ; Microglia in the AD Brain ; Cell Therapeutic Strategies for AD ; Conclusion ; Acknowledgments ; References ; Animal Models for AntineoplasticChemotherapy-Induced Alopecia; Abstract ; Introduction ; The Biology of the Hair Follicles (HFs)
9781624175886 (ebook) 1624175880 (hardback) (hbk.)
99954336392
2020687970
GBB349989 bnb
016416249 Uk
Carcinogenesis--Animal models.
Diseases--Animal models.
Animal models in research--Moral and ethical aspects.
Research.
Disease Models, Animal
Research
Ethics
Carcinogenesis
Cancérogenèse--Modèles animaux.
Maladies--Modèles animaux.
Modèles animaux dans la recherche--Aspect moral.
Recherche.
research (function)
MEDICAL--Research.
Carcinogenesis--Animal models.
Diseases--Animal models.
Electronic books.
7
Electronic books.
RC268.5
616.0273
QY 58